The preparation of samples for gene diagnosis is time‐consuming, labor‐intensive and costly. These problems can be overcome by dissolving a biological source in a strong solution of a chaotropic salt, then filtering the solution through an immobilizing membrane. Conditions exist for causing the selective immobilization of either DNA or mRNA. The resultant membrane is immediately ready for reaction with labeled gene probes.

An ambitious and highly engaging history of ideas, Feminism and Its Discontents brings together far-flung intellectual tendencies rarely seen in intimate ...

In _Michael Polanyi and His Generation_, Mary Jo Nye investigates the role that Michael Polanyi and several of his contemporaries played in the emergence of the social turn in the philosophy of science. This turn involved seeing science as a socially based enterprise that does not rely on empiricism and reason alone but on social communities, behavioral norms, and personal commitments. Nye argues that the roots of the social turn are to be found in the scientific culture and political (...) events of Europe in the 1930s, when scientific intellectuals struggled to defend the universal status of scientific knowledge and to justify public support for science in an era of economic catastrophe, Stalinism and Fascism, and increased demands for applications of science to industry and social welfare. At the center of this struggle was Polanyi, who Nye contends was one of the first advocates of this new conception of science. Nye reconstructs Polanyi’s scientific and political milieus in Budapest, Berlin, and Manchester from the 1910s to the 1950s and explains how he and other natural scientists and social scientists of his generation—including J. D. Bernal, Ludwik Fleck, Karl Mannheim, and Robert K. Merton—and the next, such as Thomas Kuhn, forged a politically charged philosophy of science, one that newly emphasized the social construction of science. (shrink)

The influential French chemist Marcelin Berthelot spoke against the use of Dalton's atomic theory and Avogadro's hypothesis in the second half of the nineteenth century. This paper argues that Berthelot conceded that atomism might be acceptable as a system of conventions, but he feared the power of such conventions in constructing a realistic picture of atoms which was not warranted empirically. Equally, Berthelot's anti-atomism was a last-ditch effort to assert the place of chemistry within the tradition of natural history and (...) to deny the possible reduction of chemical science to the laws of nineteenth-century physics. (shrink)

Obtener el consentimiento válido, libre e informado no siempre es fácil. Presupone, por un lado, la divulgación de información justa, clara y apropiada, y, por otro, la capacidad de comprenderla lo más adecuadamente posible y luego tomar una decisión. Entonces, cuando un paciente tiene impedimentos cognitivos en el largo plazo y carece de la capacidad independiente para tomar o comunicar una decisión, y cuando esta decisión se trata del final de su vida, el consentimiento puede ser muy complejo. ¿Cómo hacerlo (...) bien? El presente artículo no ofrece «la» solución, pero analiza el tema en el marco legal y ético francés. El desafío es encontrar una línea divisoria entre la beneficencia, el respeto a la autonomía y el rechazo de la «obstinación irrazonable» (que define lainutilidad en la legislación francesa). La beneficencia podría significar retirar (o retener) los tratamientos médicos en curso (quimioterapia, radioterapia, etcétera) cuando se vuelven cada vez más ineficaces y, además, son agresivos e intrusivos para el paciente (lo que conlleva una disminución de su calidad de vida). Pero cuando el paciente no puede consentir o parece estar en desacuerdo, ¿cómo podemos seguir adelante? La contribución examinará, primero, el valor de la toma de decisiones y del consentimiento del paciente en la atención médica y, luego, el papel que la familia y los cuidadores pueden desempeñar para apoyarlos. Dado que la muerte es un momento único y definitivo, no debemos olvidar que, a menudo, la experiencia de los familiares con el paciente condiciona tanto el proceso de toma de decisiones como su proceso de duelo. Finalmente, se examinarán y discutirán tres situaciones clínicas específicas, en las que se debe tomar una decisión con respecto a la retención y retirada de los tratamientos: cuando un paciente está consciente, cuando está inconsciente y no tiene instrucciones anticipadas, cuando rechaza el tratamiento a sabiendas. La lucha consiste en saber qué es lo que realmente le importa a la persona moribunda, para poder respetar sus deseos. (shrink)

This essay is a reflection of the time I have spent working with Cardinal Newman’s archive at the Birmingham Oratory. I have had a chance to stop and carefully read his letters and diaries and to see Newman as a communicator extraordinaire! I suspect that the Cardinal would have had great command of today’s social media and communications technology. His laity could have been a wider and larger audience on a virtual level. Might this be an opportunity for a sociological (...) comparison of the great writers and speakers of an earlier time with those of us in today’s media-rich world? With whom else might Newman have interacted? We may never know with certainty, but it would be fun to imagine. (shrink)

In this paper, Professor Wiggins explores the relationship between conservative economic theories and major bankruptcy reforms recently enacted by the United States Congress. First, she describes three key components of conservative economic theory as advanced by the Bush Administration and conservative scholars. These include: a strong preference for private ordering over public ordering, the promotion of private property as a means to expand personal freedom and liberty, and the encouragement of individual risk internalization. Next, she describes two theoretical components of (...) the new bankruptcy reforms. These include: a preference for creditor collection over debt relief and the promotion of individual risk internalization. Then Professor Wiggins examines two questions: First, is there meaningful theoretical symmetry between conservative economics and the new bankruptcy law? Second, is there significant operational symmetry between the two? The paper suggests theoretical convergence for two reasons: First, both conservative economics and the new bankruptcy law aim to promote private bargains over administratively adjusted ones. Second, both seek to force individuals to absorb more of the risks of financial decision-making. The paper suggests, however, that at the operational level there exists significant divergence between the aims of conservative economics and the predicted consequences of the new law. Professor Wiggins concludes, among other things, that economic conservatives should pay more rigorous attention to personal bankruptcy policy because operational asymmetry between their theories and the new legislation could blunt their ambitious economic agenda for American consumers. (shrink)

Le colloque organisé par Jérôme Bazin et Marie Frétigny à l’université de Picardie d’Amiens, avait-il besoin de se placer sous la bannière du « gender » pour analyser la question du réalisme dans la peinture du XXe siècle? Si l’hypothèse qui sous-tend cette journée – le réalisme est-il vecteur d’une autre image des femmes? – a pu être opérationnel pour le XIXe siècle, elle devient contre-productive pour le XXe. On ne sera pas surpris d’apprendre que le réalisme a renforcé les (...) stéréotypes de... (shrink)

La publication des lettres d’Isabelle de Bourbon-Parme à sa belle-sœur l’archiduchesse Marie-Christine est un événement important. Pas seulement parce que nous avons affaire à un écrit intime d’une « princesse philosophe », dont l’intelligence et l’ouverture d’esprit sont en soi dignes de notre intérêt. Mais parce qu’il s’agit de lettres d’amour à une femme, comme nous en avons peu d’exemples au xviiie siècle, et même après. Il se pourrait même que nous ayons affaire au premier écrit de cette...

This book represents a collaborative effort among the Christians and Jewish religious thinkers. They all focus on a bioethical moment at the beginning or the end of life. As members of a distinct tradition that has addressed the subject in a formal way, each one attempts an explanation of that tradition's position on the subject and suggests further developments. Healthcare issues are complex to begin with and these analyses and discussions make it a bit more likely they will be dealt (...) with on sound moral grounds. (shrink)

Introduction/Background: Moral distress and related concepts surrounding morality and ethical decision-making have been given much attention in nursing. Despite the general consensus that moral distress is an affective response to being unable to act morally, the literature attests to the need for increased clarity regarding theoretical and conceptual constructs used to describe precisely what the experience of moral distress involves. The purpose of this study is to understand how student nurses experience morally distressing situations when caring for patients with different (...) values and beliefs than their own in the clinical environment -/- Methods: This study is based on secondary analysis of participant data. The stories of eight student nurses who completed the original study were reviewed following Yin’s multiple-case study design. -/- Results: Findings suggest there is a subtle form of moral distress that has been under appreciated in the literature and differs from Jameton’s classic definition. While traditional institutional triggers to moral distress are pervasive, personal conflict as a result of differing value systems may be a moral challenge faced by nursing students working with culturally diverse patients. -/- Conclusion: Ethics education is needed in nursing school to reduce moral distress in the clinical environment. Nursing students need opportunities to develop moral reasoning skills in addition to their clinical skills. A philosophical approach to ethics education may be needed to prevent and alleviate moral distress. (shrink)

Utilizing a decade's worth of clinical experience gained since its original publication, Mary Jo Peebles builds and expands upon exquisitely demonstrated therapeutic approaches and strategies in this second edition of _Beginnings_. The essential question remains the same, however: How does a therapist begin psychotherapy? To address this delicate issue, she takes a thoughtful, step-by-step approach to the substance of those crucial first sessions, delineating both processes and potential pitfalls in such topics as establishing a therapeutic alliance, issues of trust, (...) and history taking. Each chapter is revised and expanded to include the latest treatment research and modalities, liberally illustrated with rich case material, and espouse a commitment to the value of multiple theoretical perspectives. Frank and sophisticated, yet eminently accessible, this second edition will be an invaluable resource for educators, students, and seasoned practitioners of any therapeutic persuasion. (shrink)

Gabrielle Suchon’s Treatise on Ethics and Politics offers surprising descriptions of sexual difference for an ostensibly feminist work. Stereotypically feminine traits—such as excessive emotions, chattiness, and deception—are compared to earthquakes, storms, wildfire, and apparitions. Although these descriptions may seem off-putting to modern readers, I argue that in offering these unflattering descriptions of women, Suchon is making a novel intervention in debates about the nature of sexual difference. In the Renaissance and Early Modern period, the salient question about feminine difference was (...) whether it was a preternatural deformity, and specifically a monstrosity. While most pro-woman authors argued that women were not preternatural, Suchon argues the affirmative, claiming that “persons of the sex are true wonders.” In doing so, Suchon presses on a tension at the heart of scholastic conceptions of women while also provoking an emotional response that might encourage men to reconsider whether patriarchal practices are truly to their advantage. (shrink)

The decades of the 1920s to the 1960s were a period of transformation in chemical science. The era was marked by erosion of boundaries that had often been drawn between chemistry and other scientific disciplines. In particular, theories, instruments, and mathematical approaches associated with the new physics of X-rays, the electron particle, and the electron wave enabled chemists and other physical scientists to address unsolved chemical problems of structure and mechanism and to ask new questions that further expanded and transcended (...) disciplinary borders. In turn, the historiography of these developments reflects the pluralism of chemistry in historical narratives written by scientists, historians, philosophers, and sociologists. (shrink)

Odon Lottin, O.S.B. was an historian and a moral theologian. As an historian, he studied the scholastic attention to human psychology and morality. As a theologian, he studied the roles that thought and action play in the development of the moral agent. His influence in historical and moral theology has been significant. Nonetheless, moralists and medievalists independently have appropriated his insights. No one has yet studied the relationship between his historical investigations and his moral theology. This work accomplishes that study. (...) ;This dissertation considers Lottin's contributions to both historical and moral theology. Lottin studies the medieval history and understanding of free choice, moral action, the acquired virtues and conscience. He traces this history to uncover specific ideas, expose the development of thought, recognize the emergence of consensus, and find whether satisfying resolutions were achieved. Many of his contemporaries in the manual tradition misinterpreted this history. This misinterpretation was due to their inaccurate or undeveloped historical method. And, just as there was deficiency in their method, there were significant shortcomings in the scope of their theological investigations. Thus, by looking back to history, Lottin presents a moral theology more substantive than the manuals. Each of the first four chapters of this dissertation presents Lottin's historical studies of the major debates, examines his incorporation of that material into his own contribution to the debates' resolutions, and concludes with how his work has been appropriated and where it may yet lead. The final chapter considers Lottin's contribution to the discipline of moral theology. ;Moral theology can neither be ahistorical nor impersonal. Lottin's work demonstrates the necessity of accurate history for interpretation and of critical reflection on the cause of human action. His return to medieval moral theology is a return to human agency. His agent-centered moral theology retrieves prudence and the moral virtues as dynamic means for rightly forming consciences and determining action. Historical and agent-centered moral theology is concerned with theory and practice. The theory of the moral life looks at human intentionality, the practice is its free expression; together they comprise the meaning of self-determination. (shrink)

Disons le tout de suite, le livre de l’historienne allemande Monika Siedentopf, Parachutées en terre ennemie, et le film Femmes de l’ombre, tiré de ses recherches n’ont pas grand-chose à voir ensemble. Autant le livre ouvre une nouvelle page de l’histoire de la participation des femmes à la Résistance contre l’occupant nazi, autant le film tire les ficelles d’un pseudo-héroïsme féminin qui conforte les mythes au détriment de la réalité historique. Ce qui est un comble quand on découvre la r...

Kollaboration und Konkurrenz gibt es in der Wissenschaft zwischen Individuen oder verschiedenen Gruppen, größeren Organisationen, Schauplätzen und Nationalstaaten. Die Spannung zwischen individuellem Ansehen und Gruppenmeriten oder individuellem Ehrgeiz und Gruppenleistung ist der wissenschaftlichen Arbeit inhärent und trägt zu ihrem Erfolg bei. Die Autorin vergleicht zwei soziale Modelle der Wissenschaft, die entwickelt wurden, als Wissenschaftler im 20. Jahrhundert zunehmend begannen kollaborativ zu forschen: Michael Polanyis individualistische Freie-Markt-Republik der Wissenschaft und Ludwik Flecks Denkkollektiv. Diese beiden Modelle sollten Praktiken beschreiben und Ideale für (...) die Wissenschaft im allgemeinen auf der Grundlage der Erfahrungen spezialisierter Forschungsgruppen vorschreiben. Die Arbeitsgruppen von Linus Pauling und Dorothy Crowfoot Hodgkin dienen hier der Erläuterung der beiden Modelle. Die Autorin untersucht verschiedene Auswirkungen von Paulings und Hodgkins Praktiken auf das persönliche Ansehen des Direktors und der Mitarbeiter, und schließt mit der Frage, ob eine kollektive Wissenschaft möglich ist. (shrink)

In the late spring of 1947, the experimental physicist P. M. S. Blackett succumbed to the temptations of theory. At this time, Blackett was fifty years old. He was a veteran of the Cavendish tradition in particle physics and he was on his way to an unshared award of the 1948 Nobel Prize for his experimental researches in nuclear physics and cosmic-ray physics. His photographs of cloud-chamber tracks of alpha particles, protons, electrons and positrons were well known to practitioners of (...) particle physics, even as they now grace the pages of physics textbooks.Blackett's turn toward theory in 1947 involved some risk for a well-established experimental physicist. The 3 May 1947 issue of Nature carried an announcement of his forthcoming lecture at the Royal Society:Professor P. M. S. Blackett, Langworthy Professor of Physics in the University of Manchester, will deliver a lecture on ‘The Magnetic Field of Massive Rotating Bodies’ at a meeting of the Royal Society on May 15, at 4:30 p.m.Blackett circulated a preliminary draft of his paper among colleagues in several different fields, including the geophysicist Sydney Chapman and the astrophysicist Harry Plaskett. (shrink)

La passionnante biographie de Vera Atkins réalisée par Sarah Helm à l’issue de nombreuses enquêtes en Europe, est un document précieux, qui jette une lumière nouvelle sur l’engagement des femmes dans les services secrets britanniques opérant en France durant la Seconde Guerre mondiale. Née en Roumanie en 1908, dans une famille juive aisée, Vera Rosenberg fuit le nazisme et émigra en Angleterre en 1938 avec sa mère, dont elle prit le nom d’Atkins. En 1941, elle entre comme secrétaire au SOE (...) (... (shrink)

À voir la détermination avec laquelle Berthe Morisot nous regarde, nous pourrions penser qu’elle a trouvé facilement sa place d’artiste. Une palette est esquissée sur la gauche de trois mouvements tournants. Elle porte une fleur bleue à la boutonnière, « comme une décoration », dira Mallarmé, elle se tient droite, la tête tournée vers le spectateur, et elle nous regarde de ses célèbres yeux noirs qui ont tant fasciné Manet. Paul Valéry écrira d’ailleurs au sujet de ses yeux : « (...) Berthe Mo... (shrink)

The history of women in sociology is explored here through the correspondence written by Sophonisba P. Breckinridge to Marion Talbot in the summer of 1936. Their loving letters reveal the ideas and practices of feminist pragmatism and the female world of love and ritual located in Chicago in the twentieth century. This world of professional women flourished around the social settlement Hull House and the University of Chicago during the founding years of sociology. Their lives and social thought challenge our (...) understanding of the emergence of sociology at the University of Chicago, and their ideas remain a rich resource for analyzing society today. (shrink)

SummaryThe convening of the first three Solvay Chemistry Conferences in Brussels from 1922–1928 marked an important turning point for the discipline of chemistry. Whereas much of nineteenth-century chemical endeavour had focused on compositional and functional analysis of chemical compounds, many leaders in chemistry were turning to questions of molecular dynamics by the early twentieth century. Two competing schools of chemical dynamics, which were represented at the Solvay Conferences, were a predominantly English group (Lowry, Lapworth, Robinson, Ingold) who worked out electron (...) and ionic interpretations of organic reaction mechanisms, and a French group (Perrin, Job) who developed a generalized radiation hypothesis of reaction activation. While differences in conceptual and stylistic approach separated the two schools, they agreed on the need to apply contemporary physical theory to old chemical problems, and to develop a theoretical chemistry complementary to theoretical physics. (shrink)

This paper examines human planning abilities, using as its inspiration planning techniques developed in artificial intelligence. AI research has shown that in certain problems partial‐order planners, which manipulate partial plans while not committing to a particular ordering of those partial plans, are more efficient than total‐order planners, which represent all partial plans as totally ordered. This research asks whether total‐order planning and/or partial‐order planning are accurate descriptions of human planning, and if different populations use different planning techniques. Using a simple (...) planning task modeled after tasks designed in artificial intelligence we tested 7–8 year‐old children, 11–13 year‐old children, adult controls, and adults with damage to the prefrontal cortex. We found that adults and older children exhibited performance on planning tasks of varying complexity which matched that of artificial partial‐order planners, and that this pattern of performance did not vary with multiple presentations of the planning task. In contrast, young children and adults with damage to the prefrontal cortex exhibited performance matching that of artificial total‐order planners. This pattern of performance did vary, however, with multiple presentations of the planning task, with the young children and adults with cortical damage displaying aspects of total‐order planning. In a further study we found that adolescents who had sustained damage to the prefrontal cortex as children displayed two different patterns of performance; when measures of reaction time were analyzed they revealed a pattern of performance suggestive of partial‐order plan representations. However, analyses of the adolescents' protocols revealed a pattern of performance suggestive of total‐order plan representations. The significance of these results to psychology, neuroscience, and artificial intelligence are discussed. (shrink)

Awareness of how researchers’ locations and sympathies influence their research agendas and outcomes has long been a topic for methodological consideration. This article complicates that question by considering the position of the researcher in relation to the position in society of the religions researched, and asks whether what we understand as constituting criticism or advocacy varies depending on whether the religions in question are powerful, dominating traditions or small, new, and/or beleaguered traditions. The Locations Matrix is an application of the (...) insights of standpoint analysis to the question of critical research in the sociology of religion. Researchers’ own locations—as an insider, an outsider, an apostate and/or an advocate—have consequences for the questions they ask, and to whom they address them, as well as how they interpret the data they collect. This article pushes scholars of religion to reflect on the significance of their own location in relation to the location of the religion they study. (shrink)

Scholars in the field of social studies of science marked the year 2012 as the 50th anniversary of the publication of Thomas S. Kuhn’s The Structure of Scientific Revolutions. Kuhn’s book is routinely cited as the beginning of a new intellectual movement that jettisoned logical and empiricist accounts of scientific progress in favor of sociological and psychological explanations of scientific practice. In contrast, this essay argues that the roots of the social construction of science lie earlier, in the 1930s, in (...) the political milieu, scientific careers, and intellectual debates of a generation in which Michael Polanyi was a central figure. Crucial elements in the development of Polanyi’s philosophy of science are examined, with comparisons to J. D Bernal, Karl Mannheim and others of their generation, as well as to the younger Thomas Kuhn and to Karl Popper. (shrink)